Felicia, I m sorry for your friend. But women with PCOS face difficulty conceiving. But they do conceive after few treatments or medications. PCOS gives an excess ovarian reserve with few good eggs. Which is why its difficult to conceive naturally. However, some women succeed in conceiving naturally but the majority of women find it difficult. Therefore assisted conception is one of the most effective treatments for PCOS. Clinic you have mentioned is very good. Hope she succeeds this time around.