In addition to fatigue, weight gain is often a dreaded symptom of low thyroid function. And being overweight can hinder your ability to get pregnant. Having worked with many clients who are overweight due to endocrinal issues. It does not buy the “no willpower” stigma that is placed on people who are overweight. Instead, weight problems for many people as being hormonal in nature. “One major sources of weight gain is low tissue T3 levels that are often associated with leptin resistance. Leptin is a hormone that regulates body weight and metabolism. Correction of low tissue T3 levels can result in dramatic long-term successful weight loss. Time released T3 [medications] are the most effective at restoring tissue T3 levels and are often effective when Armour thyroid, Sythroid, and Levoxyl fail to restore normal tissue levels of thyroid.